Bilimsel Araştırmalar ve Yayınlar

1. Erkan M, Kleeff J, Esposito I, Giese T, Ketterer K, Buchler MW, Giese NA, Friess H. Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis. Oncogene. 2005 Jun 23;24(27):4421-32.

2. Erkan M, Tekant Y. Molecular aspects of pancreatic cancer and new threapeutic targets (review in Turkish). Türk HPB 2005;1(2):1-5.

3. Ceyhan GO, Giese NA, Erkan M, Kerscher AG, Wente MN, Giese T, Büchler MW, Friess H. The neurotrophic factor Artemin promotes pancreatic cancer invasion: Ann surg. 2006; 244: 274-281.

4. Ceyhan GO, Bergmann F, Kadihasanoglu M, Erkan M, Park W, Gorbachevski A, Buchler MW, Giese N, Friess H. The neurotrophic factor artemin influences the extent of neural damage and growth in chronic pancreatitis. Gut. 2007; 56:534-44.

5. Erkan M, Kleeff J, Gorbachevski A, Reiser C, Mitkus T, Esposito I, Giese T, Buchler MW, Giese NA, Friess H. Periostin creates a tumor supportive microenvironment in the pancreas by sustaining fibrogenic steallate cell activity. Gastroenterology. 2007; 132:1447-64.

6. Weiwei Zhang, Mert Erkan, Ivane Abiatari, Nathalia A. Giese, Klaus Felix, Hany Kayed, Markus W. Büchler, Helmut Friess, Jörg Kleeff. Expression of Extracellular Matrix Metalloproteinase Inducer (EMMPRIN/CD147) in Pancreatic Neoplasm and Pancreatic Stellate Cells. Cancer Biol Ther. 2007; 6:218-27.

7. Kussumawidjaja G,  Kayed H, Bauer A, Giese N, Erkan M, Friess H, Kleeff J. Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells. Cancer Biol Ther. 2007;  6:367-76.

8. Michalski CW*, Oti FE*, Erkan M*, Bergmann F, Pacher P, Batkai S, Müller MW, Giese NA, Friess H, Kleeff J. Cannabinoids in pancreatic cancer: correlation with survival and pain. Int J Cancer. 2008;122(4):742-50.

* Equally contributing first author

9. Erkan M, Kleeff J, Reiser C, Hinz U, Esposito I, Friess H, Büchler MW. Pre-operative acute pancreatitis in periampullary tumors: Implications for surgical management. Digestion. 2007 Aug 7; 75:165-171

10. Michalski CW, Kleeff J, Bachmann J, lKhatib J, Erkan M , Esposito I, Friess H, Büchler MW. Second-look operation for unresectable pancreatic ductal adenocarcinoma at a high-volume center. Ann Surg Oncol. 2008; 15(1):186-92. Epub 2007 Oct 18.

11. Michalski CW*, Gorbachevski A*, Erkan M*, Reiser C, Deucker S, Bergmann F, Giese T, Weigand M, Giese NA, Friess H, Kleeff J. Mononuclear cells modulate the activity of pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitis. J Transl Med. 2007 Dec 5;5(1):63

* Equally contributing first author

12. Hüser N, Michalski CW, Erkan M, Schuster T, Rosenberg R, Kleeff J, Friess H. Systematic review and meta-analysis of the role of defunctioning stoma in low rectal cancer surgery. Ann Surg. 2008 Jul;248(1):52-60. Review.

13. Michalski CW*, Maier M* Erkan M*, Sauliunaite D, Bergmann F, Pacher P, Batkai S, Giese NA, Giese T, Friess H, Kleeff J. Cannabinoids reduce markers of inflammation and fibrosis in pancreatic stellate cells. PLoS ONE. 2008 Feb 27;3(2):e1701.

* Equally contributing first author

14. Reiser-Erkan C, Erkan M, Michalski CW, Bekasi S, Giese NA, Giese T, Friess H, Kleeff J. Expression of hypoxia-inducible proto-oncogene Pim-1 in pancreatic neoplasms. Cancer Biol Ther. 2008; 9:1353-1360

15. Erkan M, Michalski CW, Rieder S, Reiser-Erkan C, Abiatari I, Kolb A, Giese NA, Esposito I, Friess H, Kleeff J. Activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma. Clin Gastroenterol Hepatol. 2008 Oct;6(10):1155-61. Epub 2008 Jul 17

16. Michalski CW, Erkan M, Hüser N, Müller MW, Hartel M, Friess H, Kleeff J. Resection of primary pancreatic cancer and liver metastasis: a systematic review. Dig Surg. 2008;25(6):473-80. Epub 2009 Feb 12.

17. Michalski CW*, Erkan M*, Sauliunaite D, Giese T, Stratmann R, Sartori C, Giese NA, Friess H, Kleeff J. Ex vivo chemosensitivity testing and gene expression profiling predict response towards adjuvant gemcitabine treatment in pancreatic cancer. Br J Cancer. 2008 Sep 2;99(5):760-7.

* Equally contributing first author

18. Jiang X, Abiatari I, Kong B, Erkan M, De Oliveira T, Giese NA, Michalski CW, Friess H, Kleeff J. Pancreatic Islet and Stellate Cells Are the Main Sources of Endocrine Gland-Derived Vascular Endothelial Growth Factor/Prokineticin-1 in Pancreatic Cancer. Pancreatology. 2008 Dec 13;9(1-2):165-172.

19. Streit S, Michalski CW, Erkan M, Kleeff J, Friess H. Northern blot analysis for detection and quantification of RNA in pancreatic cancer cells and tissues. Nat Protoc. 2009;4(1):37-43.

20. Ceyhan GO, Deucker S, Demir IE, Erkan M, Schmelz M, Bergmann F, Müller MW, Giese T, Büchler MW, Giese NA, Friess H. Neural fractalkine expression is closely linked to pain and pancreatic neuritis in human chronic pancreatitis. Lab Invest. 2009 Mar;89(3):347-61.

21. Erkan M, Reiser-Erkan C, Michalski CW,  Deucker S, Sauliunaite D, Streit S, Esposito I, Friess H, Kleeff J. Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma. Neoplasia. 2009 May;11(5):497-508.

22. Streit S, Michalski CW, Erkan M, Friess H, Kleeff J. Confirmation of DNA Microarray-Derived Differentially Expressed Genes in Pancreatic Cancer Using Quantitative RT-PCR. Pancreatology. 2009 Aug 4;9(5):577-582.

23. Pan Z, Erkan M, Streit S, Friess H, Kleeff J. Silencing of GRP94 expression promotes apoptosis in pancreatic cancer cells. Int J Oncol. 2009 Oct;35(4):823-8.

24. Erkan M, Tekant Y. Intraductal Papillary Mucinous Neoplasms of the Pancreas. (Review in Turkish). Türk HPB. 2009;5:15-20

25. Michalski CW, Erkan M, Friess H, Kleeff J. Tumor metabolism to blood flow ratio in pancreatic cancer: helpful in patient stratification. Future Oncol. 2010 Jan;6(1):13-5.

26. Ceyhan GO, Schäfer KH, Kerscher AG, Rauch U, Demir IE, Kadihasanoglu M, Böhm C, Müller MW, Büchler MW, Giese NA, Erkan M, Friess H. Nerve growth factor and artemin are paracrine mediators of pancreatic neuropathy in pancreatic adenocarcinoma. Ann Surg. 2010 May;251(5):923-31.

27. Erkan M, Weis N, Pan Z, Schwager C,Jiang X, Wirkner X, Giese NA, Ansorge W, Debus J, Huber PE,  Friess H,  Abdollahi A, Kleeff J. Organ-, Inflammation- and Cancer Specific Transcriptional Fingerprints of Pancreatic and Hepatic Stellate Cells. Mol Cancer, 2010 Apr 23;9:88.

28. Holzapfel K, Reiser-Erkan C, Fingerle AA, Erkan M, Eiber MJ, Rummeny EJ, Friess H, Kleeff J, Gaa J. Comparison of diffusion-weighted MR imaging and multidetector-row CT in the detection of liver metastases in patients operated for pancreatic cancer. Abdom Imaging. 2011 Apr;36(2):179-84. 

29. Reiser-Erkan C, Erkan M, Ulbrich E, Nahrig J, Kleeff J. Cystic colon duplication causing intussusception in a 25-year-old man: report of a case and review of the literature. BMC Surg. 2010 Jun 23;10(1):19.

30. Kong B, Michalski CW, Hong X, Valkovska N, Rieder S, Abiatari I, Streit S, Erkan M, Esposito I, Friess H, Kleeff J. AZGP1 is a tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGFbeta-mediated ERK signaling. Oncogene. 2010 Sep 16;29(37):5146-58.

31. Wang W, Reiser-Erkan C, Raggi MC, Michalski CW, Quan L, Yupei Z, Friess H, Erkan M , Kleeff J. BHLHB2 overexpression is a positive prognostic factor indicating gemcitabine responsiveness in pancreatic cancer. Biochem Biophys Res Commun. 2010 Oct 22;401(3):422-8

32. Samkharadze T*, Erkan M*, Reiser-Erkan C, Demir IE, Bo K, Ceyhan GO, Michalski CW, Esposito I, Friess H, Kleeff J. Pigment Epithelium-Derived Factor Increases Neuropathy and Fibrosis in Pancreatic Cancer. Am J Gastroenterol. 2011 Jan 11 [Epub ahead of print].

* Equally contributing first author

33. Erkan M, Reiser-Erkan C, Michalski CW, Friess H, Kleeff J. Tumor microenvironment and progression of pancreatic cancer. Exp Oncol. 2010 Sep;32(3):128-31

34. Paron I, Berchtold S, Vörös J, Shamarla M, Erkan M, Höfler H, Esposito I. Tenascin-C Enhances Pancreatic Cancer Cell Growth and Motility and Affects Cell Adhesion through Activation of the Integrin Pathway. PLoS One. 2011;6(6):e21684. Epub 2011 Jun 29.

35. Kong B, Michalski CW, Erkan M, Friess H, Kleeff J. From tissue turnover to the cell of origin for pancreatic cancer. Nat Rev Gastroenterol Hepatol. 2011 Jul 12;8(8):467-72.

36. Erkan M, Adler G, Apte MV, Bachem MG, Buchholz M, Detlefsen S, EspositoI, Friess H, Gress T, Habisch HJ, Hwang RF, Jaster R, Kleeff J,  Klöppel G, Kordes C, Logsdon CD, Masamune A, Michalski CW, Oh J, Phillips PA, Pinzani M, Reiser-Erkan C, Tsukamoto H, Wilson J. StellaTUM: Current consensus and discussion on pancreatic stellate cell research. Gut. 2012 Feb;61(2):172-8.

* All authos have contribute equally

37. Erkan M*, Reiser-Erkan C*, Michalski CW, Kong B, Esposito I, Friess H, Kleeff J. The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance. Curr Mol Med. 2012 Mar 1;12(3):288-303.

* Equally contributing first author

38. Herrmann K.*, Erkan M.*, Dobritz  M., Schuster T., Siveke J.T., Beer A.J., Wester H.J., Schmid R.M., Friess H., Schwaiger M., Kleeff J., Buck A.K. Comparison of 3′-deoxy-3′-[18F]fluorothymidine positron emission tomography (FLT-PET) and FDG-PET/CT for the detection and characterization of pancreatic tumors. Eur J Nucl Med Mol Imaging. 2012 May;39(5):846-51.

* Equally contributing first author

39. Regel I, Kong B, Raulefs S, Erkan M, Michalski CW, Hartel M, Kleeff J. Energy metabolism and proliferation in pancreatic carcinogenesis. Langenbecks Arch Surg. 2012 Apr;397(4):507-12.

40. De Oliveira T, Abiatari I, Raulefs S, Sauliunaite D, Erkan M, Kong B, Friess H, Michalski CW, Kleeff J. Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic cancer cell phenotype. Mol Cancer. 2012 Apr 3;11(1):19

41. Mihaljevic AL, Michalski CW, Erkan M, Reiser-Erkan C, Jaeger C, Schuster T, Schuhmacher C, Kleeff J and Friess H. Standard abdominal wound edge protection with surgical dressings vs coverage with a sterile circular polyethylene drape for prevention of surgical site infections (BaFO): study protocol for a randomized controlled trial. Trials. 2012 May 15;13:57.

42. Erkan M, Hausmann S, Michalski CW, Fingerle AA, Dobritz M, Kleeff J, Friess H. The role of stroma in pancreatic cancer: diagnostic and therapeutic implications. Nat Rev Gastroenterol Hepatol. 2012 Aug;9(8):454-67.

43. Erkan M, Hausmann S, Michalski CW, Schlitter AM, Fingerle AA, Dobritz M, Friess H, Kleeff J. How fibrosis influences imaging and surgical decisions in pancreatic cancer. Front Physiol. 2012;3:389.

44. Erkan M. Antifibrotic  therapy in pancreatic diseases. Gut. 2012 Dec 22. [Epub ahead of print]

45. Erkan M. Pancreatic stellate cells and cancer. Pancreatology, 2013 Mar-Apr;13(2):106-9.

46. Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, Vandenberg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J, Karin M. Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. J Clin Invest. 2013 May 1;123(5):2231-43.

47. Erkan M. Understanding the stroma of pancreatic cancer: Coevolution of the microenvironment with the epithelial carcinogenesis. J Pathol. 2013 May 28

48. Stellwag T, Michalski CW, Kong B, Erkan M, Reiser-Erkan C, Jäger C, Meinl C, Friess H, Kleeff J. Comparative analysis of the revenues of pylorus-preserving pancreatic head resections and laparoscopic cholecystectomies as prototypic surgical procedures in the German health care system. Langenbecks Arch Surg, 2013 Aug;398(6):825-31

49. Kong Bo, Qia C, Erkan M, Kleeff J, Michalski CW. Overview on how oncogenic Kras promotes pancreatic carcinogenesis by inducing low intracellular ROS levels. Front Physiol. 2013 Sep 12;4:246

50. Balic A, Dræby Sørensen M, Trabulo SM, Sainz B Jr, Cioffi M, Vieira CR, Miranda-Lorenzo I, Hidalgo M, Kleeff J, Erkan M, Heeschen C. Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling. Mol Cancer Ther. 2014 Jul;13(7):1758-71.

51. Hausmann S, Kong B, Michalski C, Erkan M, Friess H. The role of inflammation in pancreatic cancer. Adv Exp Med Biol. 2014;816:129-51.

52. Yalcin S, Erkan M,  Ünsoy G, Parsian M, Kleeff J, Gündüz U. Effect of gemcitabine and retinoic acid loaded PAMAM dendrimer-coated magnetic nanoparticles on pancreatic cancer and stellate cell lines. Biomedicine & Pharmacotherapy, Biomed Pharmacother. 2014 Jul;68(6):737-43.

53. Irene Miranda-Lorenzo, Jorge Dorado, Enza Lonardo, Sonia Alcala, Alicia G. Serrano, Jenifer Clausell-Tormos, Michele Cioffi, Diego Megias, Sladjana Zagorac Anamaria Balic, Manuel Hidalgo, Mert Erkan, Joerg Kleeff, Aldo Scarpa, Bruno Sainz, Jr., Christopher Heeschen . Intracellular autofluorescence – A novel and universally inherited biomarker for epithelial cancer stem cells. Nat Methods. 2014 Nov;11(11):1161-9.

54. Andre´ L. Mihaljevic, Rebekka Schirren, Mine Ozer, Stephanie Ottl, Sybille Grün, Christoph W. Michalski, Mert Erkan, Carsten Jäger, Carolin Reiser-Erkan, Victoria Kehl, Tibor Schuster, Jürgen Roder, Ulf Clauer, Carolin Orlitsch, Tomas F. Hoffmann, Reinhard Lange, Thomas Harzenetter, Phillip Steiner, Milena Michalski, Karl Henkel, Josef Stadler, Georg A. Pistorius,  Anja Jahn, Robert Obermaier, Robert Unger, Roland Strunk, Frank Willeke, Holger Vogelsang, Bert Halve, Karl-Heinz Dietl, Hendrik Hilgenstock, Alexander Meyer,  Hans-Jörg Krämling, Markus Wagner, Michael H. Schoenberg, Florian Zeller, Johannes Schmidt, Helmut Friess, and Jörg Kleeff. Multicenter Double-Blinded Randomized Controlled Trial of Standard Abdominal Wound Edge Protection With Surgical Dressings Versus Coverage With a Sterile Circular Polyethylene Drape for Prevention of Surgical Site Infections. Ann Surg. 2014 Nov;260(5):730-9.

55. Berchtold S, Grünwald B, Krüger A, Reithmeier A, Hähl T, Cheng T, Feuchtinger A, Born D, Erkan M, Kleeff J, Esposito I. Collagen type V promotes the malignant phenotype of pancreatic ductal adenocarcinoma. Cancer Lett. 2015 Jan 28].

56. Kalliope N. Diakopoulos, Marina Lesina, Wörmann Sonja, Song Liang, Thomas Wartmann, Walter Halangk, Lorenz Schild, Hans Zischka, Michaela Aichler, Mert Erkan , Ihsan Ekin Demir, Christos S. Mantzoros, Heiko Witt, Roland M. Schmid, Jerzy Adamski, Hana Algül. Impaired pancreatic autophagy induces chronic atrophic pancreatitis in mice in a gender- and nutrition-dependent fashion. Gastroenterology. 2015 Mar;148(3):626-638.e17

57. JA McCarroll, G Sharbeen, J Liu, J Youkhana, D Goldstein, N, McCarthy, D Dischl, GO Ceyhan, M Erkan, A Johns, A Biankin, M, Kavallaris, PA Phillips βIII-Tubulin: A Novel Mediator of Chemoresistance and Metastases in Pancreatic Cancer. Oncotarget. 2015 Feb 10.

58. Kong B, Wu W, Cheng T, Schlitter AM, Qian C, Bruns P, Jian Z, Jäger C, Regel I, Raulefs S, Behler N, Irmler M, Beckers J, Friess H, Erkan M, Siveke JT, Tannapfel A, Hahn SA, Theis FJ, Esposito I, Kleeff J, Michalski CW. A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling. Gut. 2015 Jan 19.

59. Späth C, Nitsche U, Müller TC, Michalski CW, Erkan M, Kong B, Kleeff J. Strategies to improve the outcome in locally advanced pancreatic cancer. Minerva Chir. 2015 Feb 6.

60. Bo Kong, WeiWei Wu, Natalya Valkovska, Carsten Jaeger, Xin Hong, Ulrich Nitsche, Helmut Friess, Irene Esposito, Mert Erkan, Jorg Kleeff, and Christoph Michalski. A common genetic variation of melanoma inhibitory activity-2 labels a subtype of pancreatic adenocarcinoma with high endoplasmic reticulum stress levels. Sci Rep. Sci Rep. 2015 Feb 6

61. Cioffi M, Trabulo SM, Hidalgo M, Costello E, Greenhalf W, Erkan M, Kleeff J, Sainz B Jr, Heeschen C. Inhibition of CD47 effectively targets pancreatic cancer stem cells via dual mechanism. Clin Cancer Res. 2015 Feb 23

62. Bruno Sainz Jr, Sonia Alcala, Elena Garcia, Yolanda Sanchez-Ripoll, Maria M Azevedo, Michele Cioffi, Marianthi Tatari, Irene Miranda-Lorenzo, Manuel Hidalgo, Gonzalo Gomez-Lopez, Marta Cañamero, Mert Erkan, Jörg Kleeff, Susana García-Silva, Patricia Sancho, Patrick C Hermann, Christopher Heeschen. Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment. Gut. 2015 Apr 3.

63. Jorg Kleeff, Christoph Michalski, Bo Kong, Mert Erkan, Susanne Roth, Jens Siveke, Helmut Friess and Irene Esposito. Surgery for cystic pancreatic lesions in the post-Sendai era: a single institution experience. HPB Surg. 2015;2015:847837. doi: 10.1155/2015/847837. Epub 2015 Mar 19.

64. Daniela Stangel, Mert Erkan, Malte Buchholz, Thomas Gress, Christoph Michalski, Susanne Raulefs, Helmut Friess, Jörg Kleeff. Kif20a inhibition reduces migration and invasion of pancreatic cancer cells. J Surg Res. J Surg Res. 2015 Mar 30. pii: S0022-4804(15)00329-7.

65. Jörg Kleeff, Mert Erkan, Carsten Jäger, Maximilian Menacher, Friedemann Gebhardt, Mark Hartel. Umbilical microflora, antiseptic skin preparation and SSI in abdominal surgery. Surgical Infections. 2015 Jun 26

66. Veit Phillip, Tina Zahel, Assiye Danninger, Mert Erkan, Martin Dobritz, Jorg M. Steiner, Jorg Kleeff, Roland M. Schmid, Hana Algül. Volumetric gain of the human pancreas after left partial pancreatic resection – A CT-scan based retrospective study. Pancreatology. 2015 Jun 24.

67. Christoph W Michalski, Bo Kong, Carsten Jäger, Silke Kloe, Barbara Beier, Rickmer Braren, Irene Esposito, Mert Erkan, Helmut Friess, Jorg Kleeff. Outcomes of resections for pancreatic adenocarcinoma with suspected venous involvement: a single center experience. BMC Surg. 2015 Aug 22;15(1):100.

68. Ulrich Nitsche, Patrick Wenzel, Jens T. Siveke, Rickmer Braren, Konstantin Holzapfel, Anna M. Schlitter, Christian Stöß, Bo Kong, Lynne Cresswell, Irene Esposito, Mert Erkan, Christoph W. Michalski, Helmut Friess, Jörg Kleeff. Resectability after first-line FOLFIRINOX in initially unresectable locally advanced pancreatic cancer: A single center experience. Ann Surg Oncol. 2015 Sep 8. [Epub ahead of print]

69. Ana Santos Cravo, Edward Carter, Mert Erkan, Emma Harvey, Makoto Furutani-Seiki & Randall Mrsny Hippo pathway elements Co-localize with Occludin: A possible sensor system in pancreatic epithelial cells. Tissue Barriers, Volume 3, Issue 3, 2015.

70. Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. Nat Med. 2015 Oct;21(10):1163-Pawel K. Mazur, Alexander Herner, Stephano S. Mello, Matthias Wirth, Simone Hausmann, Timo Kuschma, Francisco J. Sanchez-Rivera, Shane Lofgren, Stephan A. Hahn, Deepak Vangala, Marija Trajkovic-Arsic, Aayush Gupta, Irina Heid, Peter B. Noël, Rickmer Braren, Mert Erkan, Jörg Kleeff, Bence Sipos, Leanne C. Sayles, Mathias Heikenwälder, Elisabeth Heßmann, Volker Ellenrieder, Irene Esposito, Tyler Jacks, James E. Bradner, Purvesh Khatri, E. Alejandro Sweet-Cordero, Laura D. Attardi, Roland M. Schmid, Guenter Schneider, Julien Sage, Jens T. Siveke.

71. Kong Bo, Tao Cheng, Weiwei Wu, Ivonne Regel, Susanne Raulefs, Helmut Friess, Mert Erkan, Irene Esposito, Jörg Kleeff, Christoph W. Michalski. Hypoxia-induced ER stress characterizes a necrotic phenotype of pancreatic cancer.  Oncotarget. 2015

Oct 13;6(31):32154-60.

72. Laparoscopic Treatment in Pancreatic Tumors (review in Turkish). Sarp Kaya Görür, Mert Erkan, Orhan Bilge, Turkiye Klinikleri J Gen Surg-Special Topics 2015;8(4)

73. Erkan M, Kurtoglu M, Kleeff J. The role of hypoxia in pancreatic cancer: a potential therapeutic target? Expert Rev Gastroenterol Hepatol. 2015 Nov 27:1-16.

74. Hausmann S, Regel I, Steiger K, Wagner N, Thorwirth M, Schlitter AM, Esposito I, Michalski CW, Friess H, Kleeff J, Erkan M.  Loss of Periostin Results in Impaired Regeneration and Pancreatic Atrophy after Cerulein-Induced Pancreatitis. Am J Pathol. 2015 Nov 27. pii: S0002-9440(15)00600-8.

75. Kong B, Cheng T, Qian C, Wu W, Steiger K, Cao J, Schlitter AM, Regel I, Raulefs S, Friess H, Erkan M, Esposito I, Kleeff J, Michalski CW. Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma. Mol Cancer. 2015 Dec 18;14(1):212

76. Zhang WW, Zhan SH, Geng CX, Sun X, Erkan M, Kleeff J, Xie XJ. Activated leukocyte cell adhesion molecule regulates the interaction between pancreatic cancer cells and stellate cells. Mol Med Rep. 2016 Oct;14(4):3627-33

77. Bo Kong, Philipp Bruns, Nora A. Behler, Ligong Chang, Anna Melissa Schlitter, Jing Cao, Andreas Gewies, Jürgen Ruland, Sina Fritzsche, Nataliya Valkovskaya, Ziying Jian, Ivonne Regel, Susanne Raulefs, Martin Irmler, Johannes Beckers, Helmut Friess, Mert Erkan, Nikola S. Mueller, Susanne Roth, Thilo Hackert, Irene Esposito, Fabian J. Theis, Jörg Kleeff, Christoph W. Michalski. Dynamic landscape of pancreatic carcinogenesis reveals early molecular networks of malignancy. Gut, Gut. 2016 Sep 19. pii: gutjnl-2015-310913.

78. Barbara Grünwald, Veronika Harant, Susanne Schaten, Monika Frühschütz, Ria Spallek, Bastian Höchst, Katharina Stutzer, Sonja Berchtold, Mert Erkan, Olga Prokopchuk, Marc Martignoni, Irene Esposito, Mathias Heikenwalder, Aayush Gupta, Jens Siveke, Paul Saftig, Percy nolle, Dirk Wohlleber, Achim Krüger.  Pancreatic pre-malignancies pave the path for liver metastasis by TIMP-1/CD63-induced hepatic stellate cell activation. Gastroenterology, Gastroenterology. 2016 Nov;151(5):1011-1024.e7.

79. Heid I, Steiger K, Trajkovic-Arsic M, Settles M, Eßwein MR, Erkan M, Kleeff J, Jäger C, Friess H, Haller B, Steingötter A, Schmid RM, Schwaiger M, Rummeny EJ, Esposito I, Siveke JT, Braren R. co-clinical assessment of tumor cellularity in pancreatic cancer. Clin Cancer Res. 2016 Sep 23. pii: clincanres.2432.2015

80. Ulrich Nitsche, Daniela Stangel, Zheng Pan, Anna Melissa, Schlitter, Irene Esposito, Ivonne Regel, Susanne Raulefs, Helmut Friess, Jörg Kleeff, Mert Erkan. Periostin and tumor-stroma interactions in non-small cell lung cancer. Oncol Lett. 2016 Nov;12(5):3804-3810. Epub 2016 Sep 14.

81. Scheufele F, Aichinger L, Jäger C, Demir IE, Schorn S, Sargut M, Erkan M, Kleeff J, Friess H, Ceyhan GO. Effect of preoperative biliary drainage on bacterial flora in bile of patients with periampullary cancer. Br J Surg. 2017 Jan;104(2): e182-e188.

82. Coskun B, Rozanes I, Erkan M, Ates S, Akpek S. Giant Celiac Arteri Aneurysm Treated with a Flow-Divertıng Multilayer Stent: Early Rupture as a Fatal Complication. J Vasc Interv Radiol. 2017 Mar;28(3):468-470.

83. Schneider R, Späth C, Nitsche U, Erkan M, Kleeff J. Contemporary strategies to improve the outcome in locally advanced pancreatic cancer. Minerva Chir. 2017 Oct;72(5):424-431.

84. Haeberle L, Steiger K, Schlitter AM, Safi SA, Knoefel WT, Erkan M, Esposito I. Stromal heterogeneity in pancreatic cancer and chronic pancreatitis. Pancreatology. 2018 May 12. pii: S1424-3903(18)30109-1.

85. Ruess DA, Heynen GJ, Ciecielski KJ, Ai J, Berninger A, Kabacaoglu D, Görgülü K, Dantes Z, Wörmann SM, Diakopoulos KN, Karpathaki AF, Kowalska M, Kaya-Aksoy E, Song L, van der Laan EAZ, López-Alberca MP, Nazaré M, Reichert M, Saur D, Erkan MM, Hopt UT, Sainz B Jr, Birchmeier W, Schmid RM, Lesina M, Algül H. Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Nat Med. 2018 Jul;24(7):954-960.

86. Neuzillet C, Tijeras-Raballand A, Ragulan C, Cros J, Patil Y, Martinet M, Erkan M, Kleeff J, Wilson J, Apte M, Tosolini M, Wilson AS, Delvecchio FR, Bousquet C, Paradis V, Hammel P, Sadanandam A, Kocher HM. Inter- and intra-tumoural heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma. J Pathol. 2018 Dec 21. doi: 10.1002/path.5224.

87. Ezequiel Tolosa, Maite Fernandez-Barrena, Eriko Iguchi, Angela McClearly-Wheeler, Ryan Carr, Luciana Almada, David Marks, Tara Hogenson, Anne Vrabel, Isaac Horn, Mert Erkan, Paola Romecin Duran, Alejandro Sarabia Gonzalez, Bo Zhou, Delphine Javelaud, Veronique Marsaud, Rondell Graham, Alain Mauviel, Sherine Elsawa, and Martin Fernandez-Zapico. GLI1/GLI2 functional interplay is required for GLI2-induced pancreatic cancer initiation. Under Review 2020

88. Ihsan Ekin Demir, Tobias Heinrich, Dominique Carty, Ömer Cemil Saricaoglu, Sarah Klauss, Steffen Teller, Timo Kehl, Carmen Reyes, Elke Tieftrunk, Maria Lazarou, Dorukhan Bahceci, Betül Gökcek, Bahar Ucurum, Matthias Maak, Kalliope Diakopoulos, Marina Lesina, Michael Schemann, Mert Erkan, Achim Krüger, Hana Algül, Helmut Friess, and Güralp Ceyhan. Targeting nNOS ameliorates the neuropathic pain due to chronic pancreatitis. JNeurosci. EBioMedicine. 2019 Aug;46:431-443. doi: 10.1016/j.ebiom.2019.07.055. Epub 2019 Aug 8.

89. Kempeneers MA, Issa Y1, Ali UA, Baron RD, Besselink MG, Büchler M, Erkan M, Fernandez-Del Castillo C, Isaji S, Izbicki J, Kleeff J, Laukkarinen J, Sheel ARG, Shimosegawa T, Whitcomb DC, Windsor J, Miao Y, Neoptolemos J, Boermeester MA; Working group for the International (IAP – APA – JPS – EPC) Consensus Guidelines for Chronic Pancreatitis. International consensus guidelines for surgery and timing of interventionin chronic pancreatitis. Pancreatology, 2019 Dec, doi: 10.1016/j.pan.2019.12.005

90. Oran DC, Lokumcu T, Inceoglu Y, Akolpoglu MB, Albayrak O, Bal T, Kurtoglu M, Erkan M, Can F, Bagci-Onder T, Kizilel S. Engineering human stellate cells for beta cell replacement therapy promotes in vitro recruitment of regulatory Tcells. Mater Today Bio. 2019 May 23;2:100006. doi: 10.1016/j.mtbio.2019.

91. Xie B, Hänsel J, Mundorf V, Betz J, Reimche I, Erkan M, Büdeyri I, Gesell A, Kerr RG, Ariantari NP, Yu H, Proksch P, Teusch N, Mrsny RJ. Pseudopterosin and O-Methylthylophorinidine suppress cell growth in a 3D spheroid co-culture model of pancreatic ductal adenocarcinoma. Bioengineering (Basel). 2020 Jun 14;7(2):E57 doi:10.3390/bioengineering/7020057.

92. Anita Balakrishnan, Mickael Lesurtel, Ajith K. Siriwardena, Stefan Heinrich, Alejandro Serrablo, Marc G.H. Besselink, Mert Erkan, Bodil Andersson, Wojciech G. Polak, Andrea Laurenzi,
Stefan W.M. Olde Damink, Frederik Berrevoet, Isabella Frigerio, Jose M. Ramia,
Thomas K. Gallagher, Susanne Warner, Shailesh V. Shrikhande, Rene Adam, Martin D. Smith, Kevin C. Conlon on behalf of the E-AHPBA Scientific and Research Committee. Delivery of hepato-pancreato-biliary surgery during theCOVID-19 pandemic: an European-African Hepato-Pancreato-Biliary Association (E-AHPBA) cross-sectional survey. HPB. 2020. doi:10.1016/j.hpb.2020.05.012

93. Taskin OC, Clarke CN, Erkan M, Tsai S, Evans DB, Adsay V. Pancreatic neuroendocrine neoplasms: current state and ongoing controversies on terminology, classification and prognostication. J Gastrointest Oncol. 2020 Jun;11(3):548-558. doi: 10.21037/jgo.2020.03.07.

94. Tolosa E, Fernandez-Barrena MG, Iguchi E, McCleary-Wheeler A, Carr R, Almada L, Flores L, Vera RE, Alfonse G, Marks D, Hogenson T, Vrabel A, Horn I, Koenig A, Safgren S, Sigafoos A, Erkan M, Romecín-Duran P, Sarabia Gonzalez A, Zhou B, Javelaud D, Marsaud V, Graham R, Mauviel A, Elsawa SF, Fernandez-Zapico ME. GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression. Biochem J. 2020 Aug 7:BCJ20200335. doi: 10.1042/BCJ20200335.

95. Xue Y, Balci S, Aydin Mericoz C, Taskin OC, Jiang H, Pehlivanoglu B, Muraki T, Memis B, Saka B, Kim GE, Bandopadhyay S, Knight J, El-Rayes BF, Sarmiento J, Reid MD, Erkan M, Basturk O, Adsay V. Frequency and clinicopathologic associations of DNA mismatch repair protein deficiency in ampullary carcinoma: Routine testing is indicated. Cancer. 2020 Aug 28. doi: 10.1002/cncr.33135.

96. Gallbladder Polyps: Correlation of size and clinicopathologic characteristics based on updated definitions. Taskin OC, Basturk O, Reid MD, Dursun N, Bagci P, Saka B, Balci S, Memis B, Bellolio E, Araya JC, Roa JC, Tapia O, Losada H, Sarmiento J, Jang KT, Jang JY, Pehlivanoglu B, Erkan M, Adsay V.PLoS One. 2020 Sep 1

97. Clinical Outcomes after total pancreatectomy: A prospective Multicenter Pan-European snapshot study. Latenstein AEJ, Scholten L, Al-Saffar HA, Björnsson B, Butturini G, Capretti G, Chatzizacharias NA, Dervenis C, Frigerio I, Gallagher TK, Gasteiger S, Halimi A, Labori KJ, Montagnini G, Muñoz-Bellvis L, Nappo G, Nikov A, Pando E, de Pastena M, de la Peña-Moral JM, Radenkovic D, Roberts KJ, Salvia R, Sanchez-Bueno F, Scandavini C, Serradilla-Martin M, Stättner S, Tomazic A, Varga M, Zavrtanik H, Zerbi A, Erkan M, Kleeff J, Lesurtel M, Besselink MG, Ramia-Angel JM; Scientific, Research Committee of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA).Ann Surg. 2020 Nov 9

98. Takashi Muraki, Burcin Pehlivanoglu, Bahar Memis, Michelle D. Reid, Takeshi Uehara, Olca Basturk, Jennifer Golia Pernicka, David S. Klimstra, William R. Jarnagin, Tetsuya Ito, Osamu Hasebe, Shinji Okaniwa, Naoto Horigome, Takeshi Hisa, Pardeep Mittal, Juan M. Sarmiento, Shishir Maithel, Jill Koshiol, Susan Tsai, Douglas Evans, Mert Erkan and Volkan Adsay. Pancreatobiliary maljunction-associated allbladder cancer is as common in the west, shows distinct clinicopathologic charactersitics and offers an invaluable model for Anatomy-Induced Reflux-Associated Physio-Chemical Carcinogenesis. Ann Surg, 2020 Nov 12.

99. Cisel Aydın Mericöz, Ezgi Hacihasanoglu, Takashi Muraki, Burcin Pehlivanoglu, Bahar Memis, Pardeep Mittal, Humbert Polito, Burcu Saka, Rhonda Everett, Juan Sarmiento, David Kooby, Shishir K. Maithel, Mert Erkan, PhD; Olca Basturk, Michelle D. Reid, Volkan Adsay. Evaluation and Pathologic Classification of Choledochal Cysts; Clinicopathologic Classification of 84 Cases from the West. Am J Surg Pathol 2021

100. Taskiran C, Vatansever D, Misirlioglu S, Giray B, Kumcular T, Arvas M, Erkan M. Complete tumor resection and demonstration of detailed anatomy of the porta hepatis in a patient with recurrent epithelial ovarian cancer. Int J Gynecol Cancer 2021 Jan 31

101. Kulle CB, Azamat IF, Vatansever D, Erus S, Tarim K, Akyoldas G, Gokler O, Deveci MA, Cakar N, Ergonul O, Agcaoglu O, Kiremit MC, Yavuz O, Kiris T, Unsaler S, Giray B, Korkmaz M, Dilege E, Kilic M, Cesur E, Solaroglu I, Altuntas O, Simsek A, Tanju S, Erkan M, Canda E, Sasani M, Hafiz AM, Kordan Y, Balik E, Bilge O, Bugra D, Taskiran C, Dilege S. Is elective cancer surgery feasible during the lock-down period of COVID-19 pandemic? Analysis of a single institutional experience of 404 consecutive patients. Journal of Surgical Oncology. J Surg Oncol. 2021 Feb 23. doi: 10.1002/jso.26436.

102. George Sharbeen, Joshua McCarroll, Anouschka Akerman, Chantal Kopecky, Janet Youkhana, John Kokkinos, Jeff Holst, Cyrille Boyer, Mert Erkan, David Goldstein, Paul Timpson, Thomas Cox, Brooke Pereira, Jessica Chitty, Sigrid Fey, Arafath Najumudeen, Andrew Campbell, Owen Sansom, Rosa Mistica Ignacio, Stephanie Naim, Jie Liu, Nelson Russia, Julia Lee, Angela Chou, Amber Johns, Anthony Gill, Estrella Gonzales-Aloy, Val Gebski, Yi Fang Guan, Marina Pajic, Nigel Turner, Minoti Apte, Thomas Davis, Jennifer Morton, Koroush Haghighi, Jorjina Kasparian, Benjamin McLean, Yordanos Setargew, Australian Pancreatic Cancer Genome Initiative APGI, and Phoebe Phillips. Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition. Cancer Res. Cancer Res. 2021 May 12:canres.2496.2020. doi: 10.1158/0008-5472.CAN-20-2496.

103. Karolin Walter, Eva Rodriguez-Aznar, Monica S Ventura Ferreira, Pierre-Oliver Frappart, Tabea Dittrich, Kanishka Tiwary, Sabine Meessen, Laura Lerma, Nora Daiss, Lucas Alexander Schulte, Frank Arnold, Valentyn Usachov, Ninel Azoitei, Mert Erkan, Andre Lechel, Tim H. Brümmendorf, Thomas Seufferlein, Alexander Kleger, Enrique Tabarés, Cagatay Günes, Fabian Beier, Bruno Sainz Jr, Patrick C. Hermann. A feedback-loop between telomerase activity and stemness factors regulates PDAC stem cells. Cancers (Basel). 2021 Jun 23;13(13):3145. doi: 10.3390/cancers13133145.

104. David Osuna de la Peña, Sara Maria David Trabulo,  Estelle Collin, Ying Liu, Shreya Sharma, Marianthi Tatari, Diana Behrens, Bruno Sainz, Mert Erkan, Rita T. Lawlor, Aldo Scarpa, Christopher Heeschen, Alvaro Mata, Daniela Loessner. Bioengineered 3D avatar models of human pancreatic cancer recapitulate in vivo tumour biology. Nature Comm. Nat Commun. 2021 Sep 24;12(1):5623. doi: 10.1038/s41467-021-25921-9.

105. Taskin OC, Reid MD, Bagci P, Balci S, Armutlu A, Demirtas D, Pehlivanoglu B, Saka B, Memis B, Bozkurtlar E, Leblebici CB, Birceanu A, Xue Y, Erkan M, Kapran Y, Baygul A, Sokmensuer C, Scarpa A, Luchini C, Basturk O, Adsay V. Infiltration pattern predicts metastasis and progression better than the T-stage and grade in pancreatic neuroendocrine tumors: a proposal for a novel infiltration-based morphologic grading. Mod Pathol. 2021 Dec 30. doi: 10.1038/s41379-021-00995-4.

106. Armutlu A, Quigley B, Choi H, Basturh O, Akkas G, Pehlivanoğlu B, Memis B, Jang KT, Erkan M, Erkan B, Balci S, Bagci P, Farris AB, Kooby DA, Martin D, Kalb B, Maithel SK, Sarmiento J, Reid MD, Adsay NV. Am J Surg Pathol, 2022. Hepatic Cysts: Reappraisal of the Classification, Terminology, Differential Diagnosis, and Clinicopathological Characteristics in 258 Cases. , Am J Surg Pathol. 2022 Sep 1;46(9):1219-1233. doi: 10.1097/PAS.0000000000001930.

107. Marta Alonso-Nocelo, Laura Ruiz-Cañas, Patricia Sancho, Kivanç Görgülü, Sonia Alcalá, Coral Perdero, Mireia Vallespinos, Marina Ochando, Elena García-García, Sara Trabulo, Paola Martinelli, Patricia Sánchez-Tomero, Carmen Sánchez Palomo, Patricia González Santamaría, Lourdes Yuste, Sonja M. Wörmann, Derya Kabacaoglu, Julie Earl, Alberto Martin, Fernando Salvador, Sandra Valle, Laura Martin-Hijano, Emilio González-Arnay, Alfredo Carrato, Mert Erkan, Laura Garcia-Bermejo, Patrick C. Hermann1, Hana Algül, Gema Moreno-Bueno, Christopher Heeschen, Francisco Portillo, Amparo Cano, and Bruno Sainz, Jr. Macrophages direct cancer cells through an OSM/LOXL2-mediated metastatic cascade in pancreatic cancer. Gut. 2023 Feb;72(2):345-359. doi: 10.1136/gutjnl-2021-325564. Epub 2022 Apr 15.

108. Viktoria Böker, Johanna Häußler, Yoshiaki Sunami, Mert Erkan, Knut Krohn, Jörg Kleeff. Analysis of genomic alterations in cáncer associated human pancreatic stellate cells. Sci Rep. April 2021

109. Use and outcome of minimally invasive pancreatic surgery in the European E-MIPS registry. van der Heijde N, Vissers FL, Manzoni A, Zimmitti G, Balsells J, Berrevoet F, Bjornsson B, van den Boezem P, Boggi U, Bratlie SO, Burdio F, Coratti A, D’Hondt M, Del Pozo CD, Dokmak S, Fara R, Can MF, Festen S, Forgione A, Fristrup C, Gaujoux S, Groot Koerkamp B, Hackert T, Khatkov IE, Keck T, Seppänen H, Lips D, Luyer M, Pittau G, Maglione M, Molenaar IQ, Pessaux P, Roeyen G, Saint-Marc O, Cabus SS, van Santvoort H, van der Schelling G, Serradilla-Martin M, Souche FR, Suarez Muñoz MÁ, Marino MV, Besselink MG, Abu Hilal M; European Consortium on Minimally Invasive Pancreatic Surgery. HPB (Oxford). 2023 Apr;25(4):400-408. doi: 10.1016/j.hpb.2022.07.015. Epub 2022 Aug 17.

110. Surgical outcomes of gallbladder cancer: the OMEGA retrospective, multicenter, international cohort study. Balakrishnan A, Barmpounakis P, Demiris N, Jah A, Spiers HVM, Talukder S, Martin JL, Gibbs P, Harper SJF, Huguet EL, Kosmoliaptsis V, Liau SS, Praseedom RK, Basu B, de Aretxabala X, Lendoire J, Maithel S, Branes A, Andersson B, Serrablo A, Adsay V; OMEGA Study Investigators.EClinicalMedicine. 2023 Apr 13;59:101951. doi: 10.1016/j.eclinm.2023.101951. eCollection 2023 May.PMID: 37125405

111. International Hepato-Pancreato-Biliary Association (IHPBA) registry study on COVID-19 infections in HPB Surgery patients. Badrudin D, Lesurtel M, Shrikhande S, Gallagher T, Heinrich S, Warner S, Chaudhari V, Koo D, Anantha S, Molina V, Calvo MP, Allard MA, Doussot A, Kourdouli A, Efanov M, Oddi R, Barros-Schelotto P, Erkan M, Lidsky M, Garcia F, Gelli M, Kaldarov A, Granero P, Meurisse N, Adam R.HPB (Oxford). 2024 Jan;26(1):102-108. doi: 10.1016/j.hpb.2023.08.007. Epub 2023 Sep 1.PMID: 38038484

112. Standardizing definitions and terminology of left-sided pancreatic resections through an international Delphi consensus. van Ramshorst TME, van Hilst J, Boggi U, Dokmak S, Edwin B, Keck T, Khatkov I, Balduzzi A, Pulvirenti A, Ahmad J, Al Saati H, Alseidi A, Ausania F, Azagra JS, Balzano G, Björnsson B, Can FM, Cillo U, D’Hondt M, Efanov M, Erkan M, Espin Alvarez F, Esposito A, Ferrari G, Groot Koerkamp B, Gumbs AA, Hogg ME, Ielpo B, Ivanecz A, Jang JY, Kleive D, Kooby DA, Luyer MDP, Marchegiani G, Menon K, Molenaar IQ, Nagakawa Y, Nakamura M, Palumbo D, Piardi T, Ramia JM, Saint-Marc O, Salti GI, Strobel O, Vollmer CM, Wei AC, White S, Yoon YS, Zerbi A, Bassi C, Berrevoet F, Chan C, Coimbra FJ, Conlon KCP, Dervenis C, Falconi M, Frigerio I, Fusai GK, De Oliveira ML, Pinna AD, Primrose JN, Sauvanet A, Serrablo A, Smadi S, Alfieri S, Berti S, Butturini G, Casadei R, Coppola R, Di Benedetto F, Ettorre GM, Giuliante F, Jovine E, Memeo R, Pietrabissa A, Portolani N, Salvia R, Siriwardena AK, Asbun HJ, Besselink MG, Abu Hilal M.Br J Surg. 2024 Apr 3;111(4):znae039. doi: 10.1093/bjs/znae039.PMID: 38686655

113. Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sánchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noël PB, Braren R, Erkan M, Kleeff J, Sipos B, Sayles LC, Heikenwalder M, Heßmann E, Ellenrieder V, Esposito I, Jacks T, Bradner JE, Khatri P, Sweet-Cordero EA, Attardi LD, Schmid RM, Schneider G, Sage J, Siveke JT. Nat Med. 2024 Jul;30(7):2090. doi: 10.1038/s41591-024-03054-y. PMID: 38816611

114. Correction: Gallbladder polyps: Correlation of size and clinicopathologic characteristics based on updated definitions.Taskin OC, Basturk O, Reid MD, Dursun N, Bagci P, Saka B, Balci S, Memis B, Bellolio E, Araya JC, Roa JC, Tapia O, Losada H, Sarmiento J, Jang KT, Jang JY, Pehlivanoglu B, Erkan M, Adsay V. PLoS One. 2024 Jul 5;19(7):e0306997. doi: 10.1371/journal.pone.0306997. eCollection 2024. PMID: 38968267

115. The legacy of a surgeon – in memoriam Dr. İsmail Demir. Demir IE, Demir E, Erkan M, Ceyhan GO, Friess H. Langenbecks Arch Surg. 2024 Sep 17;409(1):281. doi: 10.1007/s00423-024-03467-w. PMID: 39287686

116. Correlation of intratumoral mast cell quantity with psychosocial distress in patients with pancreatic cancer: the PancStress study. Sitte A, Goess R, Tüfekçi T, Pergolini I, Pfitzinger PL, Salvo-Romero E, Mota Reyes C, Tokalov S, Safak O, Steenfadt H, Gürcinar IH, Yurteri Ü, Goebel-Stengel M, Mazzuoli-Weber G, Stengel A, Erkan M, Friess H, Istvanffy R, Ceyhan GO, Demir E, Demir IE. Sci Rep. 2024 Nov 1;14(1):26285. doi: 10.1038/s41598-024-77010-8. PMID: 39487177

117. MYH knockdown in pancreatic cancer cells creates an exploitable DNA repair vulnerability. Ephraums J, Youkhana J, Raina AS, Schulstad G, Croft K, Mawson A, Kokkinos J, Gonzales-Aloy E, Ignacio RMC, McCarroll JA, Boyer C, Goldstein D, Pajic M, Haghighi KS, Johns A, Gill AJ, Erkan M, Initiative Apgi APCG, Phillips PA, Sharbeen G. Neoplasia. 2025 Mar;61:101138. doi: 10.1016/j.neo.2025.101138. Epub 2025 Feb 11. PMID: 39938155

118.       Investigating hepatic fibrosis heterogeneity by three-dimensional imaging in metabolic dysfunction-associated steatotic liver disease. Buket Yigit 1, Ekin Ozgonul 2, Omer Yaman 2, Tarik Sipahioglu 1, Burge Ulukan 1, Yagmur Cetin Tas 3, Berna Morova 2, Musa Aydin 4, Yigit Uysalli 2, Elif Demirtas 5, Mert Erkan 6, Gurkan Tellioglu 7, Dila Atak 3, Yasemin Gursoy Ozdemir 3, Sercin Karahuseyinoglu 8, Cihan Yurdaydin 1, Murat Akyildiz 1, Abhishek Sheth 9, Guruprasad Padur Aithal 9, Hale Kirimlioglu 10, Murat Dayangac 11, Onur Ferhanoglu 12, Alper Kiraz 2, Müjdat Zeybel 13

119.           Assessment of nodal staging and risk factors for nodal involvement in gallbladder cancer. Anita Balakrishnan 1 2, Petros Barmpounakis 3 4, Nikolaos Demiris 3 4, Bodil Andersson 5, Alejandro Brañes 6, Xavier de Aretxabala 7, Malin Sternby Eilard 8, Paul Gibbs 1 2, Simon J F Harper 1 2, Emmanuel L Huguet 1 2, Asif Jah 1 2, Vasilis Kosmoliaptsis 1 2, Javier Lendoire 9, Siong S Liau 1 2, Shishir Maithel 10, Jack L Martin 1 2, Colin Noel 11, Raaj K Praseedom 1 2, Alejandro Serrablo 12, Volkan Adsay 13 14; OMEGA Study Investigators

Kitaplar

  1. Friess H, Erkan M, Kleeff J, Haberkorn U, Buchler MW. The role of PET in diagnosis of pancreatic cancer and recurrence. The Pancreas: 2008. Eds. H.G. Beger, A.L. Warshaw, R.C.G. Russell, M. Buchler, D. Carr Locke, J.Neoptolemos, M.G. Sarr.
  2. Friess H, Kleeff J, Erkan M, Buchler MW. Palliative pancreatico-duodenectoy. The Pancreas: 2008. Eds. H.G. Beger, A.L. Warshaw, R.C.G. Russell, M. Buchler, D. Carr Locke, J.Neoptolemos, M.G. Sarr.
  3. Mert Erkan, Helmut Friess, Jörg Kleeff. Apoptosis. In: “Molecular Biology of Cancer”, , 2008. Ed. S. Ossinsky.
  4. Erkan M, Esposito I, Friess H, Kleeff J. Tumor-Stromal Interaction: Invasion and Metastasis. Handbook of Pancreatic Cancer: 2009. Eds: J.P. Neoptolemos, R. Urrutia, J.L. Abbruzzese, M.W. Büchler.
  5. F. Kolligs, M. Erkan, A. Graser, S. Haraida, T. Helmberger, B. Neu, M. op den Winkel, C. Trumm, C. Tympner, M. Rentsch. Hepatozelluläres Karzinom, Manual: Gastrointestinale Tumoren, Tumorzentrum München. 9. Auflage 2013
  6. Mert Erkan, Tania Brocks, Helmut Friess. The Role of Non-cancerous Cells in Cancer: Pancreatic Ductal Adenocarcinoma as a Model to Understand the Impact of Tumor Microenvironment on Epithelial Carcinogenesis. Cancer Targeted Drug Delivery. 2013 Eds: You Han Bae, Randall J. Mrsny, Kinam Park.
  7. Simone Hausmann, Bo Kong, Christoph Michalski, Mert Erkan and Helmut Friess. Role of Inflammation in Pancreatic Cancer. Advs Exp. Medicine, Biology, Vol. 816, Inflammation and Cancer. 2014,  Eds: Bharat B. Aggarwal et al.
  8. Mert Erkan, Burcu Erkan, Orhan Ağcaoğlu. Pankreasın Kistik Tümörleri. Pankreas Hastalıkları. 2019 Editör: Osman Abbasoğlu
  9. Orhan Ağcaoğlu, Burcu Erkan, Mert Erkan. Pankreas Fizyolojisi. Pankreas Hastalıkları. 2019 Editör: Osman Abbasoğlu

 

Kongre ve Sunumlar

  1. Erkan M, Kleeff J, Giese NA, Esposito I, Büchler M.W., Friess H. (Heidelberg, Germany) Loss of BNIP3 is a late event in pancreatic carcinogenesis increasing chemosesistance.25. Deutscher Pankreas-Club 2004. 18.-20. November 2004, Berlin
  2. Ceyhan GO, Müller MW, Giese NA, Erkan M, Büchler MW, Friess H (Heidelberg, Germany) Der neurotropische Wachsttumfactor Artemin induziert eine Streigerung der Krebszellinvasion im Pankreaskarzinom 25. Deutscher Pankreas-Club 2004. 18.-20. November 2004, Berlin
  3. Ceyhan GO, Kerscher AG, Bergmann F, Müller M, Giese N, Erkan M, Giese T, Büchler MW, Friess H. Neural Sprouting and Neural Hypertrophy in Pancreatic Ductal Adenocarcinoma is Related to the High Expressions of GAP-43, NGF and Artemin 37th European Pancreatic Club (EPC) Meeting. 6.-8.Juli 2005, Graz, Österreich
  4. Erkan M, Kleeff J, Esposito I,Giese T,Ketterer K, Büchler M, Giese N, Friess H (Heidelberg Germany). Loss of BNIP3 expression is a late event in pancreatic carcinogenesis contributiong to chemoresistance and worse prognosis. (Best Poster Prize) 6th Congress of the EHPBA, 25.-28. Mai 2005, Heidelberg 
  5. Kerscher A, Ceyhan GO, Müller M, Bergmann F, Giese NA, Erkan M, Giese T, Büchler MW, Friess H (Universitätsklinikum Heidelberg) Die Expression von GAP-43, NGF und Artemin korrelieren mit der gesteigerten Nervendichte und Nervenhyperophie im Pankreaskarzinom. Südwestdeutsche Gesellschaft für Gastroenterologie XVI Kongress 2.-4. Juni 2005, Heidelberg
  6. Erkan M, Kleeff J, Gorbachevski A, Reiser C, Mitkus T, Esposito I, Giese T, Buchler MW, Giese NA, Friess H. Periostin creates a tumor supportive microenvironment in the pancreas by sustaining fibrogenic steallate cell activity. EPC, 7.-10. Juni 2006, Tampere, Finnland
  7. Erkan M, Kleeff J, Gorbachevski A, Reiser C, Mitkus T, Esposito I, Giese T, Buchler MW, Giese NA, Friess H. Periostin creates a tumor supportive microenvironment in the pancreas by sustaining fibrogenic steallate cell activity. IHPBA, 3.-7. September 2006, Edinburg, Scotland
  8. Erkan M, Kleeff J, Gorbachevski A, Reiser C, Mitkus T, Esposito I, Giese T, Buchler MW, Giese NA, Friess H. Periostin creates a tumor supportive microenvironment in the pancreas by sustaining fibrogenic steallate cell activity. DPC, 23.-25. November 2006 Greifswald
  9. Maier M, Michalski CW, Erkan M, Giese NA, Friess H. Neue anti-fibrotische Effekte des Endocannabinoid-Systems in chronischer Pankreatitis. DPC, 23.-25. November 2006 Greifswald
  10. Altintas B, Ceyhan GO, Bergmann F, Erkan M, Büchler MW, Giese NA, Friess H.Der neurotropische Faktor Artemin beeinflusst das Nervenwachstum und das Ausmaß des neuralen Schadens in der chronischen Pankreatitis. DPC, 23.-25. November 2006 Greifswald, Deutschland
  11. Erkan M, Kleeff J, Reiser C, Hinz U, Esposito I, Friess H, Büchler MW. Pre-operative acute pancreatitis in periampullary tumors: Implications for surgical management. EPC, Newcastle, 2007, England
  12. Erkan M, Michalski CW, Bachmann J, AlKatib J, Esposito I, Friess H, Kleeff J, Buechler MW. Assessment of resectability after an initial diagnosis of unresectable pancreatic cancer: Impact of patient centralization. APA, Chicago, 1.-3. November 2007, USA
  13. Erkan M, Michalski CW, Rieder S, Reiser-Erkan C, Abiatari I, Kolb A, Giese NA, Esposito I, Friess H,  Kleeff J. Activated stroma is an independent prognostic marker in pancreatic ductal adenocarcinoma. DPC, 22.-24. November 2007 Dresden
  14. Erkan M, Reiser-Erkan C, Michalski CW, Deucker D, Sauliunaite D, Streit S, Esposito E, Friess H, Kleeff J. Cancer-Stellate cell interactions inhibit angiogenesis and perpetuate the hypoxia-fibrosis cycle in pancreatic cancer. 39th Annual APA-Meeting, 6.-7. November 2008, Chicago, USA
  15. Michalski CW, Herner A, Sauliunaite D, Erkan M, DeOliveira T, Abiatari I, Esposito I, Friess H, Kleeff J. AMPA-Receptor antagonism inhibits pancreatic cancer growth. 39th Annual APA-Meeting, 6.-7. November 2008, Chicago, USA
  16. Erkan M, Reiser-Erkan C, Michalski CW, Deucker D, Sauliunaite D, Streit S, Esposito E, Friess H, Kleeff J. Cancer-Stellate cell interactions inhibit angiogenesis and perpetuate the hypoxia-fibrosis cycle in pancreatic cancer.  DPC 19.-21. November 2008, Magdeburg
  17. Erkan M, Weis N, Pan Z, Schwager C, Wirkner U, Giese NA, Debus J, Friess H, Abdollahi A, Kleeff J Organ-, Inflammation- and Cancer Specific Transcriptional Fingerprints of Pancreatic and Hepatic Stellate Cells. 30. Deutscher Pankreasclub, 19.-21. November 2009, Heidelberg, Germany
  18. Samkharadze T, Erkan M, Reiser-Erkan C, Demir, IE, Kong Bo, Giese NA, Esposito I, Friess H, Kleeff J. Deregulated Expression of Pigment Epithelium-Derived Factor Increases Neuropathy and Fibrosis in Pancreatic Cancer. 30. Deutscher Pankreasclub, 19.-21. November 2009, Heidelberg, Germany
  19. Reiser-Erkan C, Erkan M, Fingerle A, Holzapfel K, Friess H, Kleeff J. Detektion von Lebermetastasen bei Patienten mit malignen Pankreastumoren durch Diffusions-MRT. 30. Deutscher Pankreasclub, 19.-21. November 2009, Heidelberg, Germany
  20. Reiser-Erkan C, Tardio M, Erkan M, Samkharadze T, Giese NA, Esposito I, Friess H, Kleef J. Membranous Claudin-10 expression is a strong positive prognostic factor in pancreatic cancer. 30. Deutscher Pankreasclub, 19.-21. November 2009, Heidelberg, Germany
  21. Erkan M, Samkharadze T, Reiser-Erkan C, Streit S, DeOliveira T, Giese NA, Espoisto I, Friess H, Kleeff J. Opposite effects of two BH3-only pro-apoptotic BCL-2 members in pancreatic cancer. 30. Deutscher Pankreasclub, 19.-21. November 2009, Heidelberg, Germany
  22. Sauliunaite D, Herner A, Michalski CW, DeOliveira T, Erkan M, Abiatari I, Kong B, Espostio I, Friess H, Kleeff J. Glutamate increases pancreatic cancer cell invasion and migration via AMPA receptor activation and K-ras-MAPK signalling. 30. Deutscher Pankreasclub, 19.-21. November 2009, Heidelberg, Germany
  23. Erkan M,  Weis N, Pan Z, Schwager C, Jiang X, Wirkner U, Giese NA, Ansorge W, Debus J,  Huber PE,  Friess H,  Abdollahi A, Kleeff J.  Organ-, Inflammation- and Cancer Specific Transcriptional Fingerprints of Pancreatic and Hepatic Stellate Cells, UEGW/WCOG GASTRO 2009, 21. – 25. November 2009, London, UK
  24. Erkan M,  Streit S,  Samkharadze T,  Reiser-Erkan C,  DeOliveira T,  Giese NA,  Esposito I,  Friess H,  Kleeff J. Opposite effects of two BH3-only pro-apoptotic Bcl-2 members in pancreatic cancer, UEGW/WCOG GASTRO 2009,  21.- 25. November 2009, London, UK
  25. Erkan M, Fingerle A, Reiser-Erkan C, Samkharadze T, Pan Z, Esposito I, Tekant Y, Gaa  J Friess H, Kleeff J. Prognostic molecular imaging in pancreatic cancer through analysis of the stromal activity. 9th World Congress of the International Hepato-Pancreato-Biliary Association, IHPBA 2010, 18.-22. April 2010, Buenos Aires, Argentinien
  26. Samkharadze T, Erkan M, Reiser-Erkan C, Demir IE, Bo K, Esposito I, Friess H, Kleeff J. Deregulated Expression of Pigment Epithelium-Derived Factor Increases Neuropathy and Fibrosis in Pancreatic Cancer. 9th World Congress of the International Hepato-Pancreato-Biliary Association, IHPBA 2010, 18.-22. April 2010, Buenos Aires, Argentinien
  27. Reiser-Erkan C, Erkan M, Fingerle A, Holzapfel K, Gaa J, Friess H, Kleeff J. Detection of liver metastasis in patients with malignant pancreatic tumors by diffusion-weighted MR imaging. 9th World Congress of the International Hepato-Pancreato-Biliary Association, IHPBA 2010, 18.-22. April 2010, Buenos Aires, Argentinien
  28. Erkan M, Samkharadze T, Reiser-Erkan C, Demir E, Michalski CW, Friess H, Kleeff J. Pigment Epithelium-Derived Factor Increases Neuropathy and Fibrosis in Pancreatic. 41st Annual Meeting of the American Pancreatic Association, APA 2010, 3.-6.November 2010, Chicago, USA.
  29. Reiser-Erkan C, Wang W, Erkan M, Michalski CW, Friess H, Kleeff J. BHLHB2 Overexpression Is a Positive Prognostic Factor Indicating Gemcitabine Responsiveness in Pancreatic Cancer. 41st Annual Meeting of the American Pancreatic Association, APA 2010, 3.-6. November 2010, Chicago, USA.
  30. Erkan M, Fingerle AA, Reiser-Erkan C, Gaa J,  Friess H,  Kleeff J. Prognostic Molecular Imaging in Pancreatic Cancer through Analysis of the Stromal Activity. 41st Annual Meeting of the American Pancreatic Association, APA 2010, 3.-6. November 2010, Chicago, USA.
  31. Reiser-Erkan C, Tardio M, Erkan M, Wang W, Samkharadze T, Friess H, Kleeff J. Membranous Claudin-10 Expression Is a Novel Positive Prognostic Factor in Pancreatic Cancer. 41st Annual Meeting of the American Pancreatic Association, APA 2010, 3.-6. November 2010, Chicago, USA. 
  32. Erkan M, Kleeff J. Does EMT contribute to the population of PSC? First meeting of the Pancreatic Star Alliance. Consensus Meeting on Pancreatic Stellate Cells. 4. March 2011, Munich, Germany.
  33. Erkan M, Friess H. Purity and contaminants of PSC isolated by different methods. First meeting of the Pancreatic Star Alliance. Consensus Meeting on Pancreatic Stellate Cells. 4. March 2011, Munich, Germany. 
  34. Erkan M, Streit S, Reiser-Erkan C, Samkharadze T, Özer M, Giese NA, Esposito I, Friess H, Kleeff J.Opposite effects of two BH3-only pro-apoptotic Bcl-2 members in pancreatic cancer. 9th congress of the EHPBA, 12-16 April 2011 Cape Town, South Africa.
  35. Erkan M, Reiser-Erkan C, Michalski C, Gertler R, Hartel M, Friess H, Kleeff J. Creation of a reference center for pancreatic surgery by team relocation – Is surgical expertise transferable? 9th congress of the EHPBA, 12-16 April 2011 Cape Town, South Africa.
  36. Reiser-Erkan C, Erkan M, Fingerle A, Gaa J, Michalski C, Friess H, Kleeff J. Prognostic molecular imaging in pancreatic cancer through analysis of the stromal activity. 9th congress of the EHPBA, 12-16 April 2011 Cape Town, South Africa.
  37. Reiser-Erkan C, Erkan M, Samkharadze T, Demir E, Michalski C, Friess H, Kleeff J. Pigment Epithelium-Derived Factor Increases Neuropathy and Fibrosis in Pancreatic Cancer. 9th congress of the EHPBA, 12-16 April 2011 Cape Town, South Africa.
  38. Michalski CW, Rieder S, Erkan M, Friess H, Kleeff J. TRIF-Dependent Type I IFN Induction Constrains Inflammatory Injury in Murine Acute Pancreatitis. 9th congress of the EHPBA, 12-16 April 2011 Cape Town, South Africa.
  39. B. Kong, C. W. Michalski, W. Wu, C. Tosolini, N. Valkovska, M. Erkan, H. Friess and J. Kleeff. HNF1A-mediated MIA2 Expression Regulates Metabolism of Pancreatic Cancer and Affects Response to Chemotherapy. 42nd Annual Meeting of the American Pancreatic Association, APA, 2.-5. November 2011, Chicago, USA.
  40. D Sauliunaite, M Erkan, A Herner, C Reiser-Erkan, T Miethke, CW Michalski, H Friess, J Kleeff. Proposal of a Step-Down Approach for the Antibiotic Therapy in Preoperatively Stented Patients with Distal Bile Duct Obstruction. 42nd Annual Meeting of the American Pancreatic Association, APA 2010, 2.-5. November 2011, Chicago, USA.
  41. M Erkan, J Kleeff, H Friess, M Apte, M Bachem. Pancreatic Star Alliance: After the First Meeting, Future Challenges. 42nd Annual Meeting of the American Pancreatic Association, APA 2010, 2.-5. November 2011, Chicago, USA.
  42. C. W. Michalski, S. Kloe, M. Erkan, H. Friess, J. Kleeff. Resection of Pancreatic Cancer invading the Portal Vein – a Case-Control Study. 42nd Annual Meeting of the American Pancreatic Association, APA 2010, 2.-5. November 2011, Chicago, USA
  43. B. Kong, C. W. Michalski, S. Kloe, M. Erkan, H. Friess, J. Kleeff Resection of pancreatic cancer invading the portal vein – a case-control study. 32. Deutscher Pankreasclub, 17.-19. November 2011, Marburg, Germany
  44. S. Hausmann, I. Regel, C. W. Michalski, M. Erkan, H. Friess, J. Kleeff. Analysis of the extracellular matrix protein periostin in early pancreatic carcinogenesis. Annual Meeting of the European Pancreatic Club, 26-29 June 2013, Zurich, Switzerland.
  45. B. Kong, W. Wu, T  Cheng, AM Schlitter, P  Bruns, C Jager, I Regel, S Raulefs, N Behler, M Irmler, J Beckers, M Erkan, FJ Theis, I  Esposito, J Kleeff, CW Michalski. Identification and Characterization of an Aldh1a3-Positive Subtype of Pancreatic Ductal Adenocarcinoma Mediated by Oncogenic Krasg12d/Erk-Mtor Axis. 44th Annual Meeting of the American Pancreatic Association, APA 30 October.-2. November 2013, Miami, USA.
  46. B Kong, N Behler, P Bruns, AM Schlitter, N Valkovska, S Fritzsche, S Raulefs, I Regel, M Erkan, FJ Theis, I Esposito, J  Kleeff, CW  Michalski. Pancreatic Progenitor Expansion, Mesenchymal Cell Proliferation and Inflammation are Required During Early Carcinogenesis. 44th Annual Meeting of the American Pancreatic Association, APA 30 October.-2. November 2013, Miami, USA.
  47. CW Michalski, C Jager, B Kong, H Friess, M Erkan, J Kleeff. A Plea for Biological Resectability Criteria in Surgery of Locally Advanced Pancreatic Cancer. 44th Annual Meeting of the American Pancreatic Association, APA 30 October.-2. November 2013, Miami, USA.
  48. İbrahim Büdeyri, Sencer Göklemez, Zheng Pan, Simone Hausmann, Christoph W. Michalski , Nathalia A. Giese3,  Helmut Friess, Jörg Kleeff, Mert Erkan. Yüksek periostin ekspresyonu pankreatik duktal adenokarsinomda bağımsız bir iyi prognostik belirteçtir. 12. Hepatopankreatobilier Cerrahi Kongresi. 1-4 Nisan 2015, Antalya, Türkiye. En iyi sunum ödülü.
  49. Sencer Göklemez, İbrahim Budeyri, Simone Hausmann, Christoph W. Michalski, Nathalia A. Giese,  Helmut Friess, Jörg Kleeff, Mert Erkan. Pankreas Duktal Adenokarsinomu’nda Proapoptotik BNIP3L’nin Hipoksi ve p53’e Bağlı İndüksiyonu Kötü Prognozla İlişkilidir. 12. Hepatopankreatobilier Cerrahi Kongresi. 1-4 Nisan 2015, Antalya, Türkiye.
  50. İbrahim Büdeyri, Sencer Göklemez, Zheng Pan, Simone Hausmann, Christoph W. Michalski , Nathalia A. Giese3,  Helmut Friess, Jörg Kleeff, Mert Erkan. High periostin expression is an independent positive prognostic factor in pancreatic ductal adenocarcinoma. 11th International Congress of the European-African Hepato-Pancreato-Biliary Association. Manchester Central. Tuesday 21st to Friday 24th April. Manchester, UK.
  51. Sencer Göklemez, İbrahim Budeyri, Simone Hausmann, Christoph W. Michalski, Nathalia A. Giese,  Helmut Friess, Jörg Kleeff, Mert Erkan. BNIP3L expression is induced by hypoxia and p53 and is associated with worsened prognosis in Pancreatic Ductal Adenocarcinoma. 11th International Congress of the European-African Hepato-Pancreato-Biliary Association. Manchester Central. Tuesday 21st to Friday 24th April. Manchester, UK.
  52. F. Scheufele, L. Aichinger, C. Jäger, M. Erkan, J. Kleeff, H. Friess, G. Ceyhan. Preoperative biliary drainage in malignant jaundice causes a shift of the biliary microbiome and aggravates antibiotic resistance.12th World congress of the IHPBA, April 20-23, 2016, Sao Paulo, Brasil
  53. Metin Kurtoğlu, Anna Melissa Schlitter, Sencer Göklemez, İbrahim Budeyri, Temesgen Tesfay, Bengi Gürses, Yersu Kapran, Helmut Freiss, Irene Esposito, Jörg Kleeff, Mert Erkan. Obstructive pancreatitis is a stronger fibrogenic stimulus than cancer-specific stellate cell activation in pancreatic ductal adenocarcinoma. Annual Meeting of the European Pancreatic Club, 6-9 July 2016, Liverpool, UK.